At Integrated Tissue Dynamics conducting ongoing research and collaborating with our extensive network of scientists and medical professionals to futher understand the functioning of the skin and related systems and nerve, skin and pain disorders is a top priority. Our scientists and researchers are actively engaged in publishing innovative and cutting-edge articles and review papers.
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Comprehensive Integrated Assessments of Normal Cutaneous and Vascular Innervation:
Fundin BT, Arvidsson J, Aldskogius H, Johansson O, Rice SN, Rice FL. (1997) A comprehensive immunofluorescence and lectin binding analysis of intervibrissal fur innervation in the mystacial pad of the rat. J.Comp.Neurol. 385: 185-206.
Fundin BT, Pfaller, K, Rice FL. (1997) Different distributions of the sensory and autonomic innervation among the microvasculature of the rat mystacial pad. J. Comp. Neurol. 389: 545-568.
Paré M, Elde R, Mazurkiewicz JE, Smith AM, Rice FL (2001) The Meissner corpuscle revised: A multi-afferented mechanoreceptor with nociceptor immunochemical properties. J. Neurosci. 21: 7236-7246.
Comprehensive Integrated Assessments of Trophin Dependencies of Cutaneous Innervation:
Rice FL, Albers, KM, Davis, BM, Silos-Santiago I, Wilkinson GA, LeMaster AM, Ernfors PJ, Smeyne RJ, Aldskogius H, Phillips HS, Barbacid M, DeChiara TM, Yancopoulos GD, Dunne CE, Fundin BT. (1998) Differential effects of various neurotrophin and trk receptor deletions on the unmyelinated innervation of the epidermis in the whisker pad of the mouse. Develop. Biol. 198: 57-81.
Cronk KM, Wilkinson GA, Silos-Santiago I. Jhaveri S, Wheeler EF, Tessarollo L, Reichardt LF, Rice FL. (2002) Promoting interactions of NT-3, trkA, trkC full length and trkC truncated receptors during the development of Merkel innervation. Development 129: 3739-3750.
Guha M, Gomes WA, Samanta J, Gupta M, Rice FL, Kessler JA (2004) Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development 131:1175-86.
Comprehensive Integrated Assessment of Keratinocyte Function in Sensory Transduction and Pain Regulation:
Khodorova A, Navarro B, Murphy J, Rice FL, Mazurkiewicz JE, Long-Woodward D, Stoffel M, Jouaville LS, Strichartz GR, Yukhananov R, Davar G (2003) Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nature Med. 9:1055-1061.
Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, Davar G, Makriyannis A, Vanderah TW, Mata HP, Malan TP (2005) CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. PNAS 102:3093-3098.
Zhao P, Barr TP, Hou Q, Dib-Hajj SD, Black JA, Albrecht PJ, Petersen KL, Eisenberg E, Rice FL, Waxman SG (2008) Voltage-gated sodium channel (Nav) expression in epidermal keratinocytes: evidence for a role in neuropathic pain. Pain 139:90-105.
Comprehensive Integrated Assessments of Cutaneous Innervation Associated with Neuropathic Conditions:
Petersen KL, Rice FL, Suess F, Berro M, Rowbotham MC, (2002) Relief of post-herpetic neuralgia by surgical removal of painful skin. Pain 98:119-126.
Albrecht PJ, Hines S, Eisenberg E, Pud D, Finlay DR, Connolly MK, Paré M, Davar G, Rice FL (2005) Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with Complex Regional Pain Syndrome. Pain 120:244-266.
Paré M, Albrecht PJ, Bodkin NL, Pittenger GL, Noto CJ, Schreyer DJ , Tigno XT, Hansen BC, Rice FL (2007) Differential Hypertrophy and Atrophy Among Various Types of Cutaneous Innervation in Monkey Glabrous Hand Skin During Aging and Naturally Occurring Type 2 Diabetes. J. Comp. Neurol . 501:543-67.