At Integrated Tissue Dynamics conducting ongoing research and collaborating with our extensive network of scientists and medical professionals to futher understand the functioning of the skin and related systems and nerve, skin and pain disorders is a top priority. Our scientists and researchers are actively engaged in publishing innovative and cutting-edge articles and review papers.
Comprehensive Integrated Assessments of Normal Cutaneous and Vascular Innervation:
Bowsher D, Woods CG, Nicholas A, Carvalho, OM, Haggett C, Tedman B, Mackenzie J, Crooks D, Mahmood N, Twomey A, Hann S, Jones D, Wymer JP, Albrecht PJ, Argoff CE, Rice FL (2009) Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation. Pain 147: 287-298.
Hough LB, Rice FL (2011) H3 receptors and pain modulation: peripheral, spinal, and brain interactions. J Pharmacol Exp Ther, 336:30-37.
Paré M, Elde R, Mazurkiewicz JE, Smith AM, Rice FL (2001) The Meissner corpuscle revised: A multi-afferented mechanoreceptor with nociceptor immunochemical properties. J. Neurosci. 21: 7236-7246.
Fundin BT, Arvidsson J, Aldskogius H, Johansson O, Rice SN, Rice FL. (1997) A comprehensive immunofluorescence and lectin binding analysis of intervibrissal fur innervation in the mystacial pad of the rat. J.Comp.Neurol. 385: 185-206.
Fundin BT, Pfaller, K, Rice FL. (1997) Different distributions of the sensory and autonomic innervation among the microvasculature of the rat mystacial pad. J. Comp. Neurol. 389: 545-568.
Comprehensive Integrated Assessments of Trophin Dependencies of Cutaneous Innervation:
Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P (2011) Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci 34: 1529-1541.
Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD (2009) Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron 64, 841–856.
Guha M, Gomes WA, Samanta J, Gupta M, Rice FL, Kessler JA (2004) Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development 131:1175-86.
Cronk KM, Wilkinson GA, Silos-Santiago I. Jhaveri S, Wheeler EF, Tessarollo L, Reichardt LF, Rice FL. (2002) Promoting interactions of NT-3, trkA, trkC full length and trkC truncated receptors during the development of Merkel innervation. Development 129: 3739-3750.
Rice FL, Albers, KM, Davis, BM, Silos-Santiago I, Wilkinson GA, LeMaster AM, Ernfors PJ, Smeyne RJ, Aldskogius H, Phillips HS, Barbacid M, DeChiara TM, Yancopoulos GD, Dunne CE, Fundin BT. (1998) Differential effects of various neurotrophin and trk receptor deletions on the unmyelinated innervation of the epidermis in the whisker pad of the mouse. Develop. Biol. 198: 57-81.
Comprehensive Integrated Assessment of Keratinocyte Function in Sensory Transduction and Pain Regulation:
Hou Q, Barr TP, Gee LE, Vickers JT, Wymer JP, Borsani E, Rodella LF, Getsios S, Burdo TH, Eisenberg E, Guha U, Lavker RM, Kessler JA, Chittur SV, Fiorino DF, Rice FL, Albrecht PJ (2011) Keratinocyte Expression of CGRPβ: Implications for Neuropathic and Inflammatory Pain Mechanisms. Pain 9:2036-2051.
Barr TP, Albrecht PJ, Hou Q, Mongin AA, Strichartz GR, Rice FL (2013) Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. PLoS One 8:e56744.
Zhao P, Barr TP, Hou Q, Dib-Hajj SD, Black JA, Albrecht PJ, Petersen KL, Eisenberg E, Rice FL, Waxman SG (2008) Voltage-gated sodium channel (Nav) expression in epidermal keratinocytes: evidence for a role in neuropathic pain. Pain 139:90-105.
Ibrahim MM, Porreca F, Lai J, Albrecht PJ, Rice FL, Khodorova A, Davar G, Makriyannis A, Vanderah TW, Mata HP, Malan TP (2005) CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. PNAS 102:3093-3098.
Khodorova A, Navarro B, Murphy J, Rice FL, Mazurkiewicz JE, Long-Woodward D, Stoffel M, Jouaville LS, Strichartz GR, Yukhananov R, Davar G (2003) Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nature Med. 9:1055-1061.
Comprehensive Integrated Assessments of Cutaneous Innervation Associated with Neuropathic and Itch Conditions:
Albrecht PJ, Hou Q, Argoff CE, Storey JR, Wymer JP, Rice FL (2013) Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (avs) in the palmar glabrous skin of fibromyalgia patients: implications for widespread deep tissue pain and fatigue. Pain Med. [Epub ahead of print].
Ross SE, Mardinly A, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner E, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Michael E. Greenberg ME (2010) Loss of inhibitory interneurons in the dorsal horn of the spinal cord gives rise to persistent pathological itch in Bhlhb5 mutant mice. Neuron, 65:886-98.
Schley M, Bayram A., Rukweid R, Dusch M, Konrad C, Benrath J, Geber C, Birklein F, Hägglöf B, Sjögren N, Gee L, Albrecht PJ, Rice FL, Schmelz M (2012) Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients. Eur J Pain 16:1414-1425.
Petersen KL, Rice FL, Farhadi M, Reda H, Rowbotham MC (2010) Natural history of cutaneous innervation following herpes zoster. Pain, 150:75-82.
Paré M, Albrecht PJ, Bodkin NL, Pittenger GL, Noto CJ, Schreyer DJ , Tigno XT, Hansen BC, Rice FL (2007) Differential Hypertrophy and Atrophy Among Various Types of Cutaneous Innervation in Monkey Glabrous Hand Skin During Aging and Naturally Occurring Type 2 Diabetes. J. Comp. Neurol . 501:543-67.
Albrecht PJ, Hines S, Eisenberg E, Pud D, Finlay DR, Connolly MK, Paré M, Davar G, Rice FL (2005) Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with Complex Regional Pain Syndrome. Pain 120:244-266.
Integrated Tissue Dynamics-INTIDYN is a therapeutic research analysis and advisory firm, not just a contract laboratory.
INTIDYN’s founders and chief scientists, Dr. Frank L. Rice and Dr. Phillip J. Albrecht, have over 30 years of published expertise in research on the skin, cutaneous innervation and vasculature. They are the foremost established experts in a holistic, comprehensive research approach that is renown for integrating high-resolution, multi-molecular morphological assessments across a wide range of nonhuman and human research models. Their ground-breaking research has been featured on the covers of such high impact journals as Nature Medicine, Neuron, PNAS and Pain.
Functioning for years as a multi-molecular morphometric core facility, our scientist's expertise continues to be sought by a vast, expanding network of international collaborators. This network includes 5 Howard Hughes Investigators and over 30 leading universities, government research institutes, and pharmaceutical companies. Our past and ongoing research maintains our leading edge in ground breaking discoveries.
Our collective experience provides unique insight and expertise in the execution, evaluation, integration and, especially, the interpretation of multi-molecular morphological analyses of the skin and cutaneous innervation. Our scientific staff can facilitate all phases of therapeutic discovery, development, and translation.
For an extensive list of current publications by INTIDYN Scientists and Researchers click on the Publications link in the lefthand column.