How to Support Further Research on Fibromyalgia and Other Types of Chronic Pain

Integrated Tissue Dynamics is a for profit research company and cannot accept tax deductable donations. Tax deductable donations to support the research of a nationwide network of pain specialists can be made to the Clinical Pain Research Program at the University of California San Diego, an American Pain Society Center of Excellence, by contacting the UC San Diego Office of Development (giving.ucsd.edu; 858-534-1610; specify area of research) or UC San Diego Center for Pain Medicine (anes-cppm.ucsd.edu; 858-657-7072). This network, referred to informally as the Neuropathic Pain Research Consortium, includes top neurologists, anesthesiologists, and research scientists at leading universities and pain treatment centers in California, Illinois, Maryland, Massachusetts, Minnesota, New York, Utah, Washington, and Wisconsin. The consortium includes renown pain specialist Dr. Charles Argoff, who was the Principal Investigator on the fibromyalgia study, and Dr. James Wymer who are in the Neurology Department at Albany Medical College,

Albrecht PJ, Hou Q, Argoff CE, Storey JR, Wymer JP, Rice FL (2013). Excessive Peptidergic Sensory Innervation of Cutaneous Arteriole-Venule Shunts (AVS) in the Palmar Glabrous Skin of Fibromyalgia Patients: Implications for Widespread Deep Tissue Pain and Fatigue.
Pain Medicine, May 20. doi: 10.1111/pme.12139 [Epub ahead of print].

Posted at the National Library of Medicine (PubMed): http://www.ncbi.nlm.nih.gov/pubmed/23691965

A description of the study for the general public can be found here.

For further information, contact:

Frank L. Rice, PhD
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Integrated Tissue Dynamics (INTIDYN)

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Phone: 866-610-7581, ext. 102

Scientific Operations

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Integrated Tissue Dynamics' key personnel bring with them over 60 years of combined experience in both basic research and applied research spanning across Academic and Industry settings.

Frank L. Rice, PhD, President and Chief Scientist

Phillip J. Albrecht, PhD, Vice-President and Deputy Chief Scientist

Dear Colleague,

Integrated Tissue Dynamics, also called INTIDYN, was established in 2008 to translate more than 35 years of experience in complex tissue analysis from the laboratory to the development of effective and safe therapeutics.

Founded by myself and Phillip J. Albrecht, Ph.D., INTIDYN specializes in assessing the impact of disease, toxins, and/or pharmacotherapies on the developmental dynamics, peripheral neural innervation,  chemistry and morphology of complex tissue.  Our focus on the multiple, integrated systems within complex tissues provides our clients with rich and comprehensive data about the cumulative physical transformations, biomolecular signaling, and gene regulations taking place in an intact living system.

All of our work is based on our proprietary INTIDYN ChemoMorphometric Analysis (ITD-CMA) platform.  ITD-CMA provides a 3-part methodology that integrates (1) multi-molecular immunochemistry, (2) tissue morphology, and (3) genomics to bridge the gap between basic research and clinical treatment.  Using validated qualitative and quantitative methodologies, ITD-CMA has been successfully applied in numerous collaborations across a variety of human specimens and animal models.

While applicable to all complex tissues, to date, INTIDYN has made especially significant progress utilizing ITD-CMA in skin, focusing on the interactions of the nervous, cardiovascular and endocrine systems in this exquisitely complex organ.  Skin, in particular, is an excellent end-point assay organ because it is exposed to a wide variety of insults, is large and contains regional variability, and is easily accessed compared to internal organs.  Skin is also one of the most complex multi-system organs in mammals, offering a cost-effective and practical site for the analysis of the integration of its many different systems (e.g., nervous, cardiovascular, endocrine, immune) and functions (e.g., protection, thermoregulation, regeneration, sensation, inflammation).

Because physical, nutritional, or xenobiotic pathologic insults often have a cascading impact across multiple disparate but integrated systems, the skin and its innervation and blood supply are the sites of hundreds of chronic, debilitating dermatopathies, neuropathies, and vasculopathies that notoriously respond poorly to existing therapeutics.  Furthermore, the complex interaction of the multiple systems within the skin make this organ highly vulnerable to environmental toxins and pharmaceutical drug side-effects.  Most importantly, its complexity also enables us to observe changes within these systems prior to overt disease or dysfunction.

We invite you to contact us to learn more about the many ways INTIDYN can work with you to investigate complex tissues and to develop the actionable data needed to advance your project.

Very Sincerely Yours,

Frank L. Rice, PhD
CEO and Chief Scientist

cover Intidyn was created to address the challenge of translating basic research into therapies...

The biopharmaceutical industry’s greatest challenge is translating basic molecular and cellular discoveries into useful therapies for humans.   

A cost-effective solution...

Integrated Tissue Dynamics (INTIDYN) provides a solution to this problem with a highly cost-effective and informative technique for understanding signaling and basic biology in the context of complex systems.  Our approach is an analytical method we call Intidyn ChemoMorphometric Analysis, or ITD-CMA™.  This technique combines multi-molecular immunochemistry, genomic and morphological analyses of complex tissue to create a comprehensive and exceptionally informative picture of what’s happening not only at the site of interest, but in adjacent sites and systems as well. Using nonhuman or human tissue biopsies to: (1) analyze the safety and efficacy of therapeutics, (2) understand disease pathology, or (3) study the effect of toxins on living tissues, ITD-CMA™ can validate therapeutic strategies and also reveal previously unknown impacts and changes in underlying functional systems, such as the nerves and vasculature, and the immune, endocrine, regenerative and thermoregulatory systems.  This technique is widely used by drug development companies and is applicable to any step in the process, from preclinical to Phase IV post-marketing studies.    

back Your Partner for developing the actionable data needed to advance your project...

INTIDYN partners with our clients to expand their knowledge and research capabilities, as evidenced by an established track record of contract work with industry, international collaborations and research publications. 

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Integrated Tissue Dynamics' key personnel bring with them over 60 years of combined experience in both basic research and applied research spanning across Academic and Industry settings.