When Integrated Tissue Dynamics, (INTiDYN) launched in 2008, we sought to translate more than 35 years of collective experience in complex tissue analysis from the laboratory to the development of effective and safe therapeutics.
INTiDYN specializes in assessing the impact of disease, toxins, and/or pharmacotherapies on the developmental dynamics, peripheral neural innervation, chemistry, and morphology of complex tissue.
The company focuses on multiple, integrated systems within complex tissues, providing clients with rich and comprehensive data about the cumulative physical changes, biomolecular signaling, and gene regulations from animal models to human disease.
The ITD-CMA advantage
All of our work is based on our proprietary INTiDYN ChemoMorphometric Analysis (ITD-CMA) platform. ITD-CMA provides a 3-part methodology that integrates (1) multi-molecular immunochemistry, (2) tissue morphology, and (3) genomics to translate the gap between basic research and clinical treatment. Using validated qualitative and quantitative methodologies, ITD-CMA has been successfully applied in numerous collaborations across a variety of animal models and human specimens.
While applicable to all complex tissues, to date INTiDYN has made especially significant progress utilizing ITD-CMA in barrier tissues like skin and gastrointestinal tract, focusing on the interactions of the nervous, cardiovascular, immune, and endocrine systems in these exquisitely complex organs.
For example, as one of the most complex organs in mammals, skin offers a cost-effective and practical site for the analysis of multi-system integration and functions (eg, physical protection, thermoregulation, regeneration, immune surveillance/inflammation, and sensation).
A focus on skin, with applications across multiple tissues
Because physical, nutritional, or xenobiotic pathologic insults often have a cascading impact across multiple disparate but integrated systems, the skin and its innervation and blood supply are the sites of hundreds of chronic, debilitating dermatopathies, neuropathies, and vasculopathies that notoriously respond poorly to existing therapeutics.
Furthermore, the complex interaction of the multiple systems within the skin make this organ highly vulnerable to environmental toxins and pharmaceutical drug side-effects. Most importantly, its complexity also enables us to observe changes within these systems prior to overt disease or dysfunction.
We invite you to contact us to learn more about the many ways INTiDYN can work with your team to develop the actionable data needed to advance your project.
Very sincerely yours,
Frank L. Rice, PhD
CEO and Chief Scientist